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Wet granulation can be broken down into three rate processes: Wetting & Nucleation, Consolidation & Growth, and Breakage & Attrition. These stages are often inseparable from each other, which hinders the characterization of the relationship between operating conditions and product properties in wet granulation processes. Single-drop granulation is a form of drop-controlled nucleation intended to isolate the Wetting & Nucleation rate process by allowing a single droplet to form a single granule upon impacting a static powder bed. Single-dropped granules (pre-nucleated granules) were charged to a mixer granulator under varied conditions to observe how the individual rate processes and resulting granulated product are affected by various pre-nucleation conditions. Batches with larger fractions of pre-nucleated granules tended to produce a larger granule size than batches with few or no pre-nucleated granules. Pre-nucleated granules on their own failed to produce a reasonable granular product, but performed well under conditions with standard liquid addition. A difference in granular product can also be identified between the formation mechanisms utilized to produce the pre-nucleated granules.